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KMID : 0379520110270010019
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한국독성학회지
2011 Volume.27 No. 1 p.19 ~ p.23
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Inhalation Exposure to Nickel Hydroxide Nanoparticles Induces Systemic Acute Phase Response in Mice
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Kang Gi-Soo
Gillespie Patricia Anne
Chen Lung-Chi
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Abstract
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It has been proposed that acute phase response can be a mechanism by which inhaled particles exert adverse effects on the cardiovascular system. Although some of the human acute phase proteins have been widely studied as biomarkers of systemic inflammation or cardiovascular diseases, there are only a few studies that investigated the role of serum amyloid P (SAP), a major acute phase protein in mice. In this study, we investigated the changes in SAP, following inhalation exposure to nickel hydroxide nanoparticles (nano-NH). We conducted 1) acute (4 h) exposure to nano-NH at 100, 500, and 1000 ㎍/㎥ and 2) sub-acute (4h/d for 3d) exposure at 1000 ㎍/㎥, then measured serum SAP protein levels along with hepatic Sap mRNA levels. The results show that inhaled nano-NH can induce systemic acute phase response indicated by increased serum SAP levels and hepatic Sap mRNA levels. To the best of our knowledge, this is the first study showing induction of SAP in response to repeated particle exposure, and the results suggest that SAP can be used as a biomarker for systemic inflammation induced by inhaled particles.
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KEYWORD
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Nickel hydroxide nanoparticles, Acute phase response, Serum amyloid P component, Inhalation, Systemic inflammation
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